LatchBio Releases a 25 Million Cell Human Spatial Transcriptomics Atlas and Agentic Spatial Curation Tools

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SAN FRANCISCO--(BUSINESS WIRE)--Sep 5, 2025--

LatchBio releases a 25M cell atlas for spatial transcriptomics, covering 45 tissue types, 63 diseases and 11 spatial technologies. This is the largest open-source human spatial atlas to date.

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The Promise of Spatial Biology

Engineering biology is moving into an era of data driven and unbiased discovery. Large volumes of high quality measurements are used to tease out targets, disease mechanisms and molecular designs otherwise difficult to identify with the unaided eye.

Spatial assays provide rich information - precise molecular position and paired high resolution images - useful in modeling cell-cell interactions or emergent properties of entire tissues. These additional measurements will be necessary for AI labs to model phenomena beyond binding and structure or for data driven translational teams to mine new hypothesis space.

"Progress in engineering biology increasingly depends on data-hungry statistical models to understand properties of living systems that exceed limits of human cognition," says Kenny Workman, CTO at LatchBio. "Large volumes of high quality spatial measurements will become increasingly important to train models and build atlases over the coming years."

AI Driven Curation at Scale

LatchBio aggregated public human studies spanning all 11 major spatial technologies using an agentic toolkit that improves per-dataset curation times by roughly 40x. The human-in-the-loop framework boosts annotation quality and consistency by incorporating information from entire papers and unstructured supplements.

Each dataset is published on console.latch.bio/data-portal as an annotated H5AD, structured with standardized ontologies for assay, cell type, condition, disease, tissue, patient ID and organism.

A detailed whitepaper on latch-curate's design and capabilities is available at https://latch.bio/latch-curate.

A White Labeled Platform for Solution Providers

Many of the companies developing these measurement technologies, like AtlasXOmics and Takara Bio, work with Latch to build and distribute white labeled data portals. These portals are bundled with their kits and help their scientific customers answer their questions faster.

“Spatial epigenomics datasets can reach terabytes in size, and scientists often struggle to establish the bioinformatics packages and infrastructure needed to analyze them. Our team has built a comprehensive set of automated pipelines and visualization tools on Latch to overcome this challenge,” says Colin Ng, VP of Business Development at AtlasXOmics. “What once took months, processing raw data into publication-ready figures, can now be accomplished in days. Latch closes the end-to-end loop for scientists, literally from raw samples to publication figures.”

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Solution Providers interested in contributing new datasets to the atlas or standing up their own white labeled portal to decrease repurchasing cycles are encouraged to contact [email protected].

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[email protected]

KEYWORD: UNITED STATES NORTH AMERICA CALIFORNIA

INDUSTRY KEYWORD: BIOTECHNOLOGY HEALTH DATA MANAGEMENT TECHNOLOGY ARTIFICIAL INTELLIGENCE

SOURCE: LatchBio

Copyright Business Wire 2025.

PUB: 09/05/2025 09:00 AM/DISC: 09/05/2025 08:59 AM

http://www.businesswire.com/news/home/20250905090341/en