Trieste, L'Aquila, Rome: the Italian genomics triangle assembles the new diploid RPE-1 genome, the missing piece for CRISPR, immediately published in California and on Nature magazine – with Dante Labs, Area Science Park, and La Sapienza University

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ROME--(BUSINESS WIRE)--Oct 10, 2025--

A few weeks ago, the USCS Genome Browser at the University of California, Santa Cruz, the bible of reference genomics, published a new and very important reference genome, Diploid RPE-1, key to the study of centromeres, thanks to the work of the Area Science Park in Trieste, the Giunta Lab at Sapienza University, Dante Labs, and the University of L'Aquila. These innovative Italian institutions have formed an international alliance with Rockefeller University in New York and the University of Tennessee to successfully complete the complex genomic assembly.

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Genome Diploid RPE-1

The RPE-1 line is not just any cell line, but one of the three most widely used in cell and molecular biology experiments worldwide, fueling discoveries in genetics, cancer research, and drug development. The team used innovative equipment such as PacBio and Oxford Nanopore technologies.

"Imagine trying to find an error in software when important files are missing from the source code," says Andrea Riposati, CEO of Dante Omics AI. "Now, we have an incredibly accurate source code for RPE-1 cells, which includes super important regions like centromeres. This is a breakthrough for all biotech companies involved in cell engineering and CRISPR gene editing."

The RPE1v1.1 assembly is available to the public via NCBI and UCSC Genome Browser.

The full article in Nature Communications: https://www.nature.com/articles/s41467-025-62428-z

More information at: danteomics.com

About Dante Omics AI

Dante Omics AI: a leader in AI-powered genomic and multi-omic solutions, dedicated to accelerating discovery and improving patient outcomes through advanced computational biology tools. The company's innovative platform combines cutting-edge artificial intelligence with high-performance computing to deliver transformative genomic analysis capabilities to research institutes, clinical laboratories, and biotechnology companies worldwide.

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CONTACT: Laura Rossi

+39 0862 191 0671

[email protected]

KEYWORD: ITALY EUROPE

INDUSTRY KEYWORD: RESEARCH TECHNOLOGY GENETICS OTHER TECHNOLOGY HEALTH TECHNOLOGY BIOTECHNOLOGY HEALTH SCIENCE ARTIFICIAL INTELLIGENCE OTHER SCIENCE

SOURCE: Dante Omics AI

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PUB: 10/10/2025 08:46 AM/DISC: 10/10/2025 08:46 AM

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